Emerin regulation of genomic organization
Emerin regulation of genomic organization Please see our recent manuscript describing emerin and HDAC3 regulate genomic organization during myogenic differentiation. http://download.springer.com/static/pdf/471/art%253A10.1007%252Fs10577-013-9381-9.pdf?auth66=1380908276_226270979ec4d5e91e901982c565b8ef&ext=.pdf Emerin genomic organization
Two recently published papers regarding emerin function in genomic organization and gene expression during myogenic differentiation
1. Demmerle J, Koch AJ, Holaska JM (2012). The nuclear envelope protein emerin binds to histone deacetylase 3 (HDAC3) and activates HDAC3 activity. J Biol Chem, Epub ahead of print, May 8. http://www.jbc.org/content/early/2012/05/08/jbc.M111.325308.long 2. Koch AJ, Holaska JM (2012). Loss of emerin alters myogenic signaling and miRNA expression in mouse myogenic progenitors. PLoS […]
Emerin inhibits Lmo7 binding to the Pax3 and MyoD promoters and expression of myoblast proliferation genes.
Dedeic Z, Cetera M, Cohen TV, Holaska JM. J Cell Sci. 2011 May 15;124(Pt 10):1691-702. Epub 2011 Apr 26.J Cell Sci. 2011 May 15;124(Pt 10):1691-702. Epub 2011 Apr 26. Abstract Link to full text X-linked Emery-Dreifuss muscular dystrophy (X-EDMD) is caused by mutations in the inner nuclear membrane protein emerin. Previous studies have shown that emerin […]