Holaska Lab

My lab studies how nuclear envelope proteins regulate fundamental cellular functions, including genomic architecture and gene expression. Mutations in nuclear envelope proteins cause a wide spectrum of diseases that include muscular dystrophy, cardiomyopathy and premature aging syndromes. We use complimentary approaches to study nuclear envelope protein function, including cell biological and biochemical assays, mouse models, genomic profiling and molecular modeling. By using diverse approaches to these particular problems we aim to identify gene networks that are regulated by distinct nuclear envelope proteins during development and in disease.